In 1964 Bell, Mukerji & Loraine described a new bioassay method for the quantitative determination of luteinizing hormone (LH) depending on the depletion of ovarian cholesterol after i.p. administration of the hormone to intact immature rats pretreated with pregnant mare serum gonadotrophin and human chorionic gonadotrophin. The pretreatment used in this method was identical with that employed by Schmidt-Elmendorff & Loraine (1962) in the ovarian ascorbic acid depletion (OAAD) test of Parlow (1958). In view of the marked difference in sensitivity between these two bioassay procedures it seemed desirable to ascertain whether the dose-response curve of the OAAD method is affected by the very small doses of LH similar to those used in the ovarian cholesterol depletion (OCD) test.
Three OAAD assays on 135 rats obtained from the University of Edinburgh Small Animal Breeding Station were conducted. The procedure used was similar to that of Schmidt-Elmendorff & Loraine (1962) except
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Print ISSN: 0022-0795
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