THE METABOLISM OF CORTISOL BY HUMAN EXTRA-HEPATIC TISSUES

in Journal of Endocrinology
Author:
J. S. JENKINS
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SUMMARY

The extra-hepatic metabolism of cortisol in man has been studied in vitro by incubation of [4-14C]cortisol with tissue slices.

Kidney tissue was the most active, followed by prostate; thyroid, skeletal muscle and synovial membrane were much less effective. Cortisone was quantitatively the predominant metabolite but C-20-reduced derivatives of cortisol and cortisone were also present. There was evidence for the oxidation of the side chain by kidney and prostate, but no ring A-reduced compounds were found.

Kidney slices did not reduce the 11-oxo group of cortisone but this reaction proceeded readily with liver slices.

Some evidence for extra-hepatic metabolism of cortisol in vivo by the tissues of the forearm was obtained by infusing [4-14C]cortisol into the brachial artery.

 

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