An oral glucose tolerance test was performed in eight patients with gonadal dysgenesis and in two a diabetic response was found. The plasma insulin levels were estimated in response to the glucose load and were abnormal in five out of the six patients examined.
The blood sugar response to the standard insulin tolerance test was normal in six patients and showed increased insulin sensitivity in two. Plasma cortisol concentration was measured in response to the hypoglycaemia induced by insulin and in seven out of the eight patients rose considerably indicating a normally functioning pituitary-adrenal system.
The sera of all eight patients were examined for auto-antibodies and were essentially negative.
Possible reasons for the abnormalities in carbohydrate metabolism are discussed and it is suggested that gonadal dysgenesis may predispose to diabetes.