Female rats treated during the early postnatal period with a sufficient amount of oestrogen develop a severe disorder of the regulatory mechanisms of the oestrous cycle with subsequent anovulation and sterility (Greene, Burrill & Ivy, 1939; Greene & Burrill, 1941; Turner, 1941; Wilson, Hamilton & Young, 1941). We have studied the cytological changes in the anterior pituitary of such animals.
Ten female rats of our laboratory strain, aged 5 days, received a single s.c. injection of 1·25 mg. oestradiol dipropionate in 0·1 ml. peanut oil. The animals were killed at the age of 200 days and their ovaries and pituitaries were removed.
Histological investigation of the ovaries showed numerous large vesicular follicles and hypertrophied interstitial cells in the interfollicular spaces. Corpora lutea were absent. The animals were persistently in oestrus in agreement with the findings of Takasugi (1952) who reported that short-term injections of oestrogens given to female rats during
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