19-Hydroxylation of the steroid molecule is an obligatory step in the conversion of androgens to oestrogens. It has been shown (Földes, Koref, Fehér & Steczek, 1964) that the urinary excretion of individual oestrogens decreases after the administration of 2-methyl-1,2-bis-(3-pyridyl)-1-propanone (SU4885).
The aim of the present communication is to show that SU 4885 inhibits the transformation of androstenedione to oestrogens in the rat ovary in vitro. The following trivial names are used: androstenedione = androst-4-ene-3,17-dione; oestradiol = oestra-1,3,5(10)-triene-3,17β-diol; oestrone = 3-hydroxy-oestra-1,3,5(10)-trien-17-one.
Female rats of the Wistar strain, weighing 180–250 g., received two injections of 50 units chorionic gonadotrophin (HCG, Choriogonin, Richter, Budapest) 24 and 16 hr. before the ovaries were removed. For each assay, 18 animals were used, six of which also received s.c. 10 mg. SU 4885 (Metopirone, Ciba, Basel) 40, 24 and 16 hr. before death. The ovaries were removed, halved and distributed (12 halved ovaries, 250–350 mg./vessel) between six vessels each
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