NEUTRAL STEROID SULPHATION AND OESTROGEN BIOSYNTHESIS IN VITRO BY A FEMINIZING LEYDIG CELL TUMOUR OF THE TESTIS

in Journal of Endocrinology
Authors:
C. G. PIERREPOINT
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K. GRIFFITHS
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J. K. GRANT
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J. S. S. STEWART
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DOI:
https://doi.org/10.1677/joe.0.0350409
Volume/Issue:
Volume 35: Issue 4
Article Type:
Research Article
Page Range:
409–417
Online Publication Date:
Aug 1966
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SUMMARY

The metabolism of [7α-3H]pregnenolone and [4-14C]dehydroepiandrosterone by a feminizing Leydig cell tumour from a man has been studied in vitro.

The tumour formed the 3β-sulphoxy derivatives of pregnenolone, 17α-hydropregnenolone and dehydroepiandrosterone.

Carbon-labelled oestradiol-17β and tritiated oestriol were isolated from the tumour indicating that the probable pathway of the formation of oestriol was by way of 16α-hydroxylated steroids not involving DHA or oestradiol.

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Print ISSN:
0022-0795
Online ISSN:
1479-6805
Page(s):
9
Article Type:
Research Article
Print Publication Date:
01 Jan 1966
Online Publication Date:
Aug 1966