N-Acetylneuraminic acid (NANA) is a component of the follicle-stimulating hormones (FSH) of several mammalian species, some of which have been reported to lose activity after treatment with neuraminidase (Bourrillon & Got, 1960; Gröschel & Li, 1960; Gottschalk, Whitten & Graham, 1960). Amir, Barker, Butt & Crooke (1966) have shown that human FSH is inactivated by neuraminidase and have found that NANA itself has hitherto unsuspected biological properties.
Synthetic N-acetyl-d-neuraminic acid (d-NANA) (Koch-Light Laboratories Ltd.) was dissolved in water and carefully neutralized with a dilute sodium hydroxide solution. When injected into intact immature, spayed, or hypophysectomized mice no follicle-stimulating, luteinizing or oestrogenic activity of d-NANA could be demonstrated. In doses up to 8 mg. d-NANA produced occasionally a slight increase in the uterine weight of immature mice, and in the ovarian weight of mice given 40 i.u. human chorionic gonadotrophin simultaneously. However no dose-response
Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
| Sept 2018 onwards | Past Year | Past 30 Days | |
|---|---|---|---|
| Full Text Views | 0 | 0 | 0 |
| PDF Downloads | 2 | 0 | 0 |
Online ISSN: 1479-6805
Print ISSN: 0022-0795
Strengthening biomedical communities
to advance science and health
CONTACT US
Bioscientifica Ltd | Starling House | 1600 Bristol Parkway North | Bristol BS34 8YU | UK
Bioscientifica Ltd | Registered in England no 3190519
