Trophoblast derived from mouse eggs removed from the oviduct (tubal eggs) and transplanted to the kidney readily bring about degeneration of the adrenal X-zone in the intact female mouse. A similar amount of trophoblast from the same source was ineffective in ovariectomized mice. Trophoblast derived from transplanted uterine blastocysts, on the other hand, caused X-zone degeneration both in the intact and ovariectomized, and in prepubertally castrated males. The effect was abolished by hypophysectomy. It is suggested that trophoblast which develops from transplanted tubal eggs stimulates the pituitary to secrete a gonadotrophin which induces the interstitial ovarian tissue to secrete androgen which causes X-zone degeneration. Trophoblast from transplanted uterine blastocysts has the same effect and may additionally stimulate the secretion of adrenocorticotrophic hormone which, by direct action, would stimulate adrenal androgen production and thus produce degeneration of the X-zone.
Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
| Sept 2018 onwards | Past Year | Past 30 Days | |
|---|---|---|---|
| Full Text Views | 0 | 0 | 0 |
| PDF Downloads | 2 | 0 | 0 |
Online ISSN: 1479-6805
Print ISSN: 0022-0795
Strengthening biomedical communities
to advance science and health
CONTACT US
Bioscientifica Ltd | Starling House | 1600 Bristol Parkway North | Bristol BS34 8YU | UK
Bioscientifica Ltd | Registered in England no 3190519
