The ability of cells from the zona fasciculata and zona reticularis of the horse adrenal cortex to transform [7α-3H]pregnenolone, [4-14C]progesterone, [7α-3H]17α-hydroxypregnenolone and [4-14C]17α-hydroxyprogesterone to cortisol in vitro was investigated.
It was found that: (1) Both types of cell form cortisol from these steroids. (2) The transformation is greater in fascicular cells. (3) The formation of 17α-hydroxyprogesterone from pregnenolone (via either progesterone or 17α-hydroxypregnenolone) is slower that the subsequent formation of cortisol from 17α-hydroxyprogesterone. (4) The formation of 17α-hydroxyprogesterone from 17α-hydroxypregnenolone is rate-limiting in cortisol formation, but is about 2·4 times faster in fascicular than in reticular cells. (5) 17α-Hydroxylation of progesterone is also faster in fascicular than in reticular cells.
Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
| Sept 2018 onwards | Past Year | Past 30 Days | |
|---|---|---|---|
| Full Text Views | 1 | 0 | 0 |
| PDF Downloads | 2 | 0 | 0 |
Online ISSN: 1479-6805
Print ISSN: 0022-0795
Strengthening biomedical communities
to advance science and health
CONTACT US
Bioscientifica Ltd | Starling House | 1600 Bristol Parkway North | Bristol BS34 8YU | UK
Bioscientifica Ltd | Registered in England no 3190519
