The effect of methylenedianiline on the increased testicular 17-oxosteroid secretion caused by human chorionic gonadotrophin (HCG) was studied in dogs.
A single i.v. administration of 20 i.u. HCG/kg. produced a marked increase in the secretion of testicular 17-oxosteroids. The increase in the secretion occurred within 15 min. after the injection and was sustained during the 4 hr. of observation. At the maximum rate of secretion, an i.v. injection of 25 mg. or 100 mg./kg. of methylenedianiline caused a substantial diminution in testicular 17-oxosteroid secretion. This decrease occurred within 15 min. after the injection; the response was reversible. The effect is believed to be due to a block of androgen biosynthesis in the testis.
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