Lipid and cholesterol synthesis is very active in the foetal rabbit liver and large amounts of lipid appear in the foetal liver at term and disappear in the first few days of life (Dawkins, 1966). The possibility that lipid metabolism at this stage may be regulated by the foetal pituitary is suggested by the observation that human anencephalic foetuses, which have a hypoplastic pituitary, have an abnormally thick pannus of subcutaneous fat (Angevine, 1938). This view is supported by the reports that foetal hypophysectomy by decapitation in the rabbit produces an increase in total body fat (Jost & Picon, 1958), in liver fat (Beam, 1960) and in blood cholesterol (Bearn & Pilkington, 1963). This work has now been extended to include studies on blood triglyceride concentrations.
The foetuses were decapitated on the 22nd day of gestation by the intra-amniotic method (Beam & Pilkington, 1963): The uterine wall is incised and
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