The uptake, metabolism and intracellular localization of [6,7-3H]oestradiol-17β in male hamster kidneys and liver have been studied. Three doses of [6,7-3H]oestradiol were injected, and tissues were removed 30 min. and 4 hr. later. The tissue radioactivity was separated into 'free', 'glucosiduronide', 'sulphate' and 'polar' fractions. Most of the radioactivity was associated with the 'polar' fraction. Oestrone and oestradiol were identified in liver and kidney. Cell fractionation showed that most of the radioactivity was in the 'soluble' fraction. Neither the amount of [6,7-3H]oestradiol injected nor the time after injection at which the tissues were taken affected the metabolites or their intracellular location.
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