Marmorston, Crowley, Myers, Stern & Hopkins (1965) have reported that premenopausal women with breast cancer excreted significantly less androsterone and etiocholanolone than a control group. In an earlier paper Grattarola (1964) had found in such patients that endometrial specimens obtained before the menstrual period rarely showed a secretory pattern, a high percentage showing a moderate to a marked degree of proliferation. The urinary excretions of 11-deoxy-17-ketosteroids in premenopausal women with breast cancer was therefore studied with the aim of observing whether urinary excretion of androgen metabolites differs in patients with an ovulatory pattern of the premenstrual endometrium and patients with a proliferative or hyperplastic premenstrual endometrium showing that ovulation did not occur.
Thirty-two premenopausal patients with breast cancer, aged 30–47 yr., were examined. All had a breast removed 4–12 months before this study was started; all were free from metastases and none had been treated with hormones. Seventeen of these
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