The development of characteristic castration changes in the anterior pituitary of rats ovariectomized at the age of 1 and 5 days (Presl, Horský, Henzl & Jirásek, 1963) means that the feedback mechanism between the ovaries and the diencephalohypophysial system becomes established early postnatally, before sexual maturity. The observed changes suggested that the ovaries already produce oestrogens during this period. The purpose of the present work was to obtain direct evidence of oestrogen production in 10-day-old female rats, i.e. when steroid-3β-ol dehydrogenase is already present in the ovaries (Presl, Jirásek, Horský & Henzl, 1965).
Wistar rats bred in our laboratory were used. The animals were given heparin s.c. (10-day-old animals received 500 i.u., all others 1000 i.u.) and were killed by decapitation 45 min. later. Ovariectomized animals were killed 4 weeks after the operation. Adrenalectomy was performed 3 weeks after ovariectomy and the animals were killed 10 days later. For each
Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
| Sept 2018 onwards | Past Year | Past 30 Days | |
|---|---|---|---|
| Full Text Views | 5 | 0 | 0 |
| PDF Downloads | 3 | 0 | 0 |
Online ISSN: 1479-6805
Print ISSN: 0022-0795
Strengthening biomedical communities
to advance science and health
CONTACT US
Bioscientifica Ltd | Starling House | 1600 Bristol Parkway North | Bristol BS34 8YU | UK
Bioscientifica Ltd | Registered in England no 3190519
