Robertson & Rakha (1965) have shown that chlorpromazine effectively blocks ovulation in the ewe when administered immediately after the animals had become sexually receptive. From the results of Robertson & Rakha (1966) it appears that the suppressive action of chlorpromazine was very likely related to the blockade of the ovulatory release of luteinizing hormone (LH) that occurs at this time. Their results indicate also that there is a discharge of follicle-stimulating hormone (FSH) from the pituitary prior to oestrus, and it can be postulated that it is this discharge that precipitates the onset of oestrus. It was of interest to determine whether chlorpromazine when given over the normal period of release of FSH would block the onset of sexual receptivity in the ewe.
Twelve intact, cyclic, Cheviot ewes were maintained under prolonged (72 hr.) sedation with chlorpromazine, the treatment starting at the beginning of the 15th day of the cycle,
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