Hydroxylation at the angular C-19 methyl group is thought to be a necessary step for the biosynthesis of oestrogens since it is the first stage of aromatization (Meyer, 1955; Ryan, 1959).
Griffiths (1963) found that the dose of metyrapone which produced an inhibition of 11β-hydroxylase activity in the adrenal of the golden hamster also produced a decrease in the activity of the 19-hydroxylase. This indicated the use of metyrapone as an inhibitor of oestrogen biosynthesis. Földes, Koref, Fehér & Steczek (1964) suggested that metyrapone affects the adrenal and the ovary; they reported a decrease in the excretion of oestrone, 17β-oestradiol and oestriol with a particularly marked decrease of the oestradiol fraction, both on the day of treatment and on the day after. The same authors refer to a simultaneous increase of androsterone and aetiocholanolone originating possibly from androst-4-ene-3,17-dione, the concentration of which may increase with the decreased formation of 19
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