In the uterus of pregnant mice an increase in uptake of tritiated uridine occurs between days 2 and 3 of pregnancy, followed by a further increase from day 4 onwards. Uridine uptake changes in the same manner in pseudopregnant mice up to day 4, but thereafter declines to a minimum at day 6. The non-pregnant horn of the unilaterally pregnant mouse shows the same changes as the uterus of the pseudopregnant mouse. The results suggest that implantation occurs during a period of declining ovarian stimulation of the uterus and that the increased uptake of uridine in pregnant mice is stimulated locally by implantation.
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