It has been shown (Julesz, Faredin & Tóth, 1966) that the human male and female axillary and pubic hair contains large amounts of dehydroepiandrosterone (DHA) and that a significant part of this steroid is present in the form of its sulphate ester (DHA-sulphate) (Tóth, Faredin & Julesz, 1967). Gallegos & Berliner (1967) recently described the conjugation in vitro of DHA to DHA-sulphate (DHA-S) by human male abdominal skin slices. The present communication deals with the metabolism of DHA in female skin.
Normal abdominal skin (dermis and epidermis) was obtained from women during appendectomy. The skin sample (1 g.) was chopped with scissors into cubes of 1–2 mm. diameter and incubated with 1,122,880 disintegrations/min. (d.p.m.) [4-14C]DHA (Radiochemical Centre, Amersham, sp.act. 7·8 μc/μm) in 10 ml. Krebs—Ringer—phosphate solution, pH = 7.4 (containing 200 mg. glucose/100 ml., 10−3m-NAD, 10−3m-NADP and 10−3m-ATP)
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