Stilboestrol treatment increases the urinary excretion of corticosteroids in male guinea-pigs (Zondek & Burstein, 1952). This effect is presumably caused by stimulation of the output of adrenocorticotrophin (ACTH) from the hypophysis, but this has not been proved. The following experiments in hypophysectomized animals show that the effect is not produced in the absence of the hypophysis.
Four-month-old guinea-pigs of a randomly bred strain, anaesthetized intraperitoneally with 25 mg. tribromoethanol/kg. (Avertin, Winthrop Laboratories, New York) were hypophysectomized by the parapharyngeal approach (McPhail, 1934). The animals were allowed to recover in a warm (21–24°) draught-free room. Each animal was fed by pipette with warm milk 3 times a day until able to feed independently on cabbage and diet SG 1 (Dixon's, Ware). Cortisone was given daily (20 mg./kg., s.c.) for 1 week after the operation and the drinking water was replaced by a NaCl solution.
Guinea-pigs successfully hypophysectomized showed a smaller
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