Mammary-gland development and milk secretion were induced in virgin adult female Fischer rats by treatment with perphenazine (Trilafon) for 5 days. The drug, however, failed to induce similar lactation in ovariectomized adult animals or in juvenile rats unless the animals were pretreated with small quantities of oestradiol, indicating that when the ovaries are absent, or almost inactive as in juvenile rats, oestradiol-priming is a prerequisite for perphenazine-induced lactation.
When perphenazine was given to adult rats starting at early dioestrus, the following changes occurred: (1) a continuous dioestrus ensued lasting about 7 days after the end of treatment; (2) the ovaries were predominantly occupied by corpora lutea, and (3) a typical pseudopregnant 'lucid zone' appeared in the uterine endometrium.
It is concluded that perphenazine treatment most likely stimulated secretion of luteotrophic hormone, which in rats seems to be identical with prolactin in its promotion of lactogenesis.
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