The median urinary excretion of 17-oxosteroids in 22 normal unanaesthetized dogs was 0·06 (range: 0·02–0·24) mg./kg. body weight/24 hr. 17-Oxosteroid excretion increased markedly after the administration of dehydroepiandrosterone and androstenedione, while testosterone caused only a very small increase.
The median urinary excretion of total 17-hydroxycorticosteroids (17-OHCS) in 21 dogs was 0·16 (range: 0·06–0·320 mg./kg. body weight/24 hr. This was calculated to amount to about 50–60% of the cortisol produced.
Stimulation with corticotrophin (ACTH) resulted in an increase of urinary 17-OHCS and of plasma 11β-OHCS levels, but 17-oxosteroid excretion was only slightly increased.
In 27 dogs the median plasma 11β-OHCS level was 4·0 (range: 1·3–9·7) μg./100 ml. at 8.00 hr. and 3·6 (range: 0·4–7·0) μg./100 ml. at 17.00 hr. In eight dogs 3-hourly plasma 11β-OHCS estimations were done; six of these animals showed a diurnal variation comparable to that in man.
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Online ISSN: 1479-6805
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