THE PLASMA CORTICOTROPHIN RESPONSE TO INSULIN HYPOGLYCAEMIA, LYSINE-VASOPRESSIN AND METYRAPONE IN PIGS

in Journal of Endocrinology
Authors:
R. A. DONALD
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S. SALISBURY MURPHY
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J. D. N. NABARRO
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SUMMARY

The coated charcoal immunoassay method was applied to the measurement of the corticotrophin (ACTH) response to insulin hypoglycaemia, lysine-vasopressin, metyrapone and surgical stress in female piglets. The maximum ACTH responses average 392 picograms (pg.)/ml. (insulin hypoglycaemia), 111 pg./ml. (lysine-vasopressin) and exceeded 350 pg./ml. after metyrapone. The time relationships between blood sugar, 11-hydroxycorticosteroid and ACTH levels were also examined. Despite constant infusion rates, the ACTH response to lysine-vasopressin was not sustained. Previous administration of dexamethasone suppressed the response to insulin hypoglycaemia and lysine-vasopressin.

 

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