A recent study has established that after simultaneous administration of [3H]corticosterone 21-sulphate (B-S) plus [14C]corticosterone (B), an important fraction of B-S was transformed into the glucuronides of the polar corticosterone metabolites (Pasqualini, 1967). These metabolites appeared in the urine mainly from 8 hr. after the administration of corticosterone and its 21-sulphate. In the previous study we suggested that most of this radioactive material represented hexahydro-derivatives of corticosterone. In the present investigations these results have been confirmed and the structure of the principal constituent of this fraction has been established.
Two healthy men each received i.v. a mixture of 20 μc [3H]B-S (s.a.: 0·1 μc/μg.) and 3·3 μc [14C]B (s.a.: 0·06 μc/μg.). The method of extraction from the urine and the fractionation procedure for the conjugated material have been described previously (Pasqualini, 1967). The urinary glucuronide fraction (0–4, 4–8 and 8–24 hr. collection after administration of the
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