In rats made hypothyroid by thyroidectomy, serum creatine kinase (CK) activity appears to be unchanged or slightly reduced. This is in contrast to the increased values reported in myxoedematous man. Brain CK activity was unchanged and heart activity was only slightly reduced in these animals. Skeletal muscle CK activity, however, was more definitely reduced and the reduction was highly significant. The lower tissue enzyme activity in heart and skeletal muscle could be explained by a reduction in total protein concentration of the tissue extracts from the thyroidectomized animals, since the specific activity of the enzyme from these tissues was essentially unchanged as compared with controls.
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