A preliminary study has been carried out to determine the amount of milk-ejection activity (oxytocin) in jugular blood of the goat after electrical stimulation of the basal hypothalamus to afford a comparison with the levels known to occur during parturition and hand-milking in this species (Folley & Knaggs, 1965, 1966). Seventeen British Saanen goats (12 castrated male, two ovariectomized female, three intact female) were used. A polyethylene cannula was inserted in the jugular vein immediately before the experiment; anaesthesia was induced with cyclopropane:oxygen, the head was fixed in a stereotaxic instrument and anaesthesia was maintained with halothane:oxygen. A stimulating electrode, inclined at an angle of 3° from vertical to avoid damaging the superior sagittal sinus, was lowered into the hypothalamus using stereotaxic co-ordinates for the goat brain (Tindal, Knaggs & Turvey, 1968). In the earliest experiments a bipolar or very fine monopolar electrode was used. However, a monopolar
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