It has been postulated that the increased rate of corticosteroid formation in the adrenal gland after corticotrophin stimulation is due to an increase in the rate of formation of NADPH or an increase in the availability of a corticosteroid precursor (Haynes & Berthet, 1957; Koritz & Peron, 1958). It has also been shown that adrenal tissue has a high level of glucose 6-phosphate dehydrogenase which generates NADPH (Kelly, Nielson, Johnson & Vestling, 1955). In this communication we would like to present evidence that in the human adrenal gland, exogenous NADPH stimulates cortisol synthesis in vivo.
The patients were all cases of advanced breast cancer with widespread metastases undergoing bilateral oophorectomy and adrenalectomy. In nine of them 2 μc of [7α-3H]pregnenolone was injected via the inferior phrenic artery and the adrenal venous blood was collected for 12 min. after the injection. In four patients, 2 μc of radioactive pregnenolone
Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
| Sept 2018 onwards | Past Year | Past 30 Days | |
|---|---|---|---|
| Full Text Views | 2 | 1 | 0 |
| PDF Downloads | 4 | 0 | 0 |
Online ISSN: 1479-6805
Print ISSN: 0022-0795
Strengthening biomedical communities
to advance science and health
CONTACT US
Bioscientifica Ltd | Starling House | 1600 Bristol Parkway North | Bristol BS34 8YU | UK
Bioscientifica Ltd | Registered in England no 3190519
