In the marsupial Trichosurus vulpecula, the decay curve of plasma renin concentration against time, during a period of 4 hr. immediately after either bilateral nephrectomy or i.v. injection of a partially purified homologous renin, could be resolved into two exponential components. The curves in both types of experiment were similar, suggesting a simple twopool system of renin distribution. The half-times of the first and second components were 11·1 ± 2·6 (s.d.) and 217 ± 71·5 min. respectively.
As in dogs, the initial volume of distribution of injected renin was equivalent to approximately 10% of body weight. Using this value, and the derivative of the post-nephrectomy decay curve at the time of removal of the second kidney, the renin production rate at this time was calculated to be in the range of 123–1170 units/min. This calculation was justified by demonstrating that the surgical manipulations did not cause any increase in plasma renin concentration. Renal renin production rates, measured in other possums from the difference in renin concentrations of arterial and renal venous plasma, were within the range calculated from the postnephrectomy decay curves.
Metabolic clearance rates calculated from the post-nephrectomy decay curves averaged 3·5 ml./min./kg.; and those calculated from the post injection decay curves averaged only 1·9 ml./min./kg. Circulatory changes, due to nephrectomy or renin injection, are the most likely reasons for this discrepancy.
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