Different degrees of permanent gonadal insufficiency and deviations of sexual behaviour have been produced in male and female rats treated with high doses of androgen or oestrogen during the perinatal phase of hypothalamic organization (Harris, 1964; Dörner, 1968, 1969a, b). In this study, the endogenous sex hormone level was increased by gonadotrophin administration in this critical period of hypothalamic differentiation and its effect on gonadal function and sexual activity in adult rats of both sexes was investigated.
Twenty-nine male and 20 female Sprague-Dawley rats were injected s.c. daily for the first 14 days of life with 10 i.u. human chorionic gonadotrophin (HCG) in 0·1 ml. water. Twenty-six males and 18 females, which received the solvent only, served as controls. On day 15, eight animals of each group were killed. Vaginal smears from the remaining females were examined daily during the 3rd month of life and sexual behaviour and fertility
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