DEVELOPMENT OF GOITRE AFTER METHYLTHIOURACIL TREATMENT OF MICE WITH HYPOTHALAMIC LESIONS

in Journal of Endocrinology
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SUMMARY

Lesions aimed at the area of the paraventricular hypothalamic nuclei were made by means of stereotaxic electrocoagulation in intact and gonadectomized mice, which were subsequently treated with methylthiouracil. Lesions could be placed with an acceptable degree of precision and with moderate postoperative mortality. Correctly placed lesions made in intact females and castrated males caused a marked inhibition of goitre development, indicating a depressed secretion of thyrotrophin. However, in intact males and spayed females inhibition of goitre formation could not be demonstrated convincingly.

 

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