Acetic acid extracts of toad choroid plexuses had an antidiuretic effect in water-loaded ethanol-anaesthetized rats, whose pattern was similar to that produced by toad neural lobe extracts and by arginine vasopressin. The antidiuretic activity of the choroid plexus extracts was completely abolished by treatment with sodium thioglycollate. Antidiuretic activity per milligram choroid plexus was about four times higher in the plexus of the third ventricle than in the plexus of the fourth ventricle. The antidiuretic activity of both choroid plexuses increased progressively during the summer and autumn and reached its peak in October; it then fell to very low or undetectable levels during the middle of the winter and spring.
The choroid plexuses also showed seasonal variations in their ultrastructural organization, which might be related to the seasonal variations of their antidiuretic activity.
The origin of the substance(s) responsible for the antidiuretic activity in the choroid plexuses is discussed.
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