Datta & Chaudhury (1968) have shown that [Asp4]-oxytocin, [Ile8]-oxytocin and [Ser4]-oxytocin block the antidiuretic effect of antidiuretic hormone (ADH) when administered 10 min. before it. Further investigations on the mechanism of this blocking effect of [Asp4]-oxytocin are reported in this communication. The first series of experiments were carried out to see if [Asp4]-oxytocin could also block the vasopressor effect of ADH. Adult male rats (250–300 g.) were anaesthetized with urethane (1.4 g./kg.) and the blood pressure recorded on a smoked drum through a cannula in the carotid artery. The external jugular vein was cannulated for administration of the drugs. ADH (arginine vasopressin) was administered at a dose ranging from 0·25 to 4·0 m−u. before and 10 min. after administration of [Asp4]-oxytocin in eight animals. The same dose of ADH was administered before and after [Asp4]-oxytocin which
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