Cyproterone acetate exerted strong anti-androgenic effects on the seminal vesicles of mice, but failed to affect androgen-dependent aggressive behaviour in mice. Groups of adult castrated male mice were treated with (1) testosterone propionate (TP); (2) TP plus cyproterone acetate; or (3) neither TP nor cyproterone acetate, for 5 weeks and given weekly tests for aggressive behaviour. The seminal vesicles were removed after the last test for aggression. Although treatment of mice with cyproterone acetate in combination with TP almost totally suppressed the stimulatory effect of TP on seminal vesicle weight, aggressive behaviour was not affected by cyproterone acetate. It was concluded that cyproterone acetate probably does not influence central nervous tissue and non-neural tissue in the same manner.
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