The induction of ovarian tumours in mice by 9,10-dimethyl-1,2-benzanthracene (DMBA) is preceded by the disappearance of oocytes and follicles.
The effect of DMBA on the oocyte population was determined in immature and in mature mice by performing total and differential oocyte counts at different intervals after oral and intraperitoneal administrations of the carcinogen.
In orally treated animals the number of small oocytes was quickly reduced followed by a decrease in the number of growing and large oocytes; in addition, in intraperitoneally treated animals, some growing and large oocytes were directly destroyed.
The sensitivity of the germ cells to DMBA was independent of the age of the animals.
In normal mice, as well as in immature mice treated with DMBA, the number of small oocytes determined the proportion which was stimulated to develop into growing and large oocytes.
Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
| Sept 2018 onwards | Past Year | Past 30 Days | |
|---|---|---|---|
| Full Text Views | 5 | 0 | 0 |
| PDF Downloads | 0 | 0 | 0 |
Online ISSN: 1479-6805
Print ISSN: 0022-0795
Strengthening biomedical communities
to advance science and health
CONTACT US
Bioscientifica Ltd | Starling House | 1600 Bristol Parkway North | Bristol BS34 8YU | UK
Bioscientifica Ltd | Registered in England no 3190519
