The distribution and localization of 125I-labelled bovine parathyroid hormone was studied by radioautography in adult rats. The principal site of localization was the proximal convoluted tubule of the kidney. Light and variable localization was present in the liver, but no significant amount of label was found in muscle, spleen, bone or articular cartilage. The localization of this labelled compound in the proximal convoluted tubule suggests that this region degrades 125I-labelled parathyroid hormone.
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