THE EFFECT IN VITRO OF THYROXINE, GLUCAGON, THYROTROPHIN AND ANTITHYROID DRUGS ON 'USUAL' AND 'ATYPICAL' HUMAN PLASMA CHOLINESTERASE

in Journal of Endocrinology
Author: MARY WHITTAKER
View More View Less
Restricted access

SMUMARY

Concentrations of thyroxine above 10-7m inhibited the activity of the 'usual' and 'atypical' human plasma cholinesterase in vitro. The 'atypical' enzy mewas more readily inhibited and the ratio of the I50 atypical: I50 usual indicates that the hormone can be used as a differential inhibitor to identify the two phenotypes. Similar results were obtained with thiourea, but the action of thiouracil appeared to differ in so far as this inhibited both enzymes to the same extent. Neither glucagon nor thyroid stimulating hormone had any effect.

 

      Society for Endocrinology

Sept 2018 onwards Past Year Past 30 Days
Abstract Views 72 29 1
Full Text Views 31 0 0
PDF Downloads 11 0 0