Dramatic changes have been observed at the light microscopic and ultrastructural levels in the neurosecretory axons of the distal stump of the transected proximal neurohypophysis (Dellmann & Owsley, 1968, 1969; Sterba & Brückner, 1969; Dellmann & Rodriguez, 1970). Besides phagocytic pituicytes (Dellmann & Owsley, 1968, 1969; Sterba & Brückner, 1969), large cells have been reported to occur in the median eminence (Dellmann & Owsley, 1968), characterized by a very light-staining cytoplasm and granules stainable with paraldehyde fuchsin. This report deals with the ultrastructure of these cells and their possible significance.
The investigations were carried out on grass frogs, Rana pipiens, killed 6 and 12 hr., 1, 1·5, 2, 6 and 9 days after transection of the proximal neurohypophysis. The areas adjacent to the lesion were fixed in situ with a threefold aldehyde mixture (Rodriguez, 1969), carefully dissected out and processed according to the procedure described elsewhere (Dellmann & Rodriguez, 1970);
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