The presence of a gonadotrophin-inhibiting substance (GIS) which inhibits the stimulatory effects of human chorionic gonadotrophin (HCG) and ovine luteinizing hormone (LH) on the mouse uterus was demonstrated in human urine (Soffer, Futterweit & Salvaneschi, 1961; Soffer, Salvaneschi & Futterweit, 1962). GIS also has a suppressive effect on ovulation induced with pregnant mare serum gonadotrophin (PMS) and HCG in immature mice (Ota, Dronkert & Gates, 1968a, b). However, its mode of action is still obscure. Recently, Hipkin (1969) postulated that GIS inhibits the release of endogenous gonadotrophin but does not inhibit exogenous HCG or LH directly. It is of interest to know whether the ovulation-inhibiting property of GIS is effective against both exogenous and endogenous ovulatory gonadotrophins.
The mice used were F1 hybrids (BALB/cx 129), raised and maintained in a room lit for 14 h daily (5.00–19.00 h). Females were treated at 19–26 days of age with PMS
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