Two rabbits were injected intravenously with [4-14C]progesterone and the bile and urine collected for 6 h. The crude bile was administered through an intraduodenal cannula to four rabbits as a single injection, and to three rabbits at a constant rate of infusion for 1·5 h. Bile and urine were collected hourly for up to 7 h. In the single injection experiments 42·3–64·4% of the radioactivity was excreted in the bile and 3·8–13·5% in the urine in 5–6 h. After constant rate infusion 35·4–64·8% and 4·7–9·5% of the radioactivity was excreted in the bile and urine respectively during 6–7 h. The hourly recovery of radioactivity in the neutral fractions of bile and urine decreased with time, whereas radioactivity not accounted for increased. Acidic metabolites represented an insignificant proportion of both biliary and urinary metabolites after enterohepatic recirculation.
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