The capacity of specific antisera against growth hormone (GH) to inhibit the biological activity of this hormone has been previously described. Most experiments were carried out on hypophysectomized rats, and the biological activity of GH in the tibia assay could be neutralized by its specific antiserum or crossreacting antisera (Hayashida & Contopoulos, 1967), or by anti-pituitary serum (Anigstein, Rennels & Anigstein, 1960). Pierpaoli & Sorkin (1967, 1968) observed considerable impairment of body growth, often manifested as a runting syndrome, and extensive degeneration of lymphoid tissues after administration of antisera to pituitary extracts of bovine GH to young mice.
The purpose of this study was to investigate the effect of specific antibodies to rat GH (RGH) on young rats. Special attention was paid to the morphology and function of the lymphoid system. Because the thymus plays an important role in development of the lymphoid system early in life, newborn rats were
Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
Sept 2018 onwards | Past Year | Past 30 Days | |
---|---|---|---|
Full Text Views | 0 | 0 | 0 |
PDF Downloads | 1 | 1 | 0 |