Incubation of slices of adrenal tissue from a newborn anencephalic infant with [14C]pregnenolone and [3H]progesterone yielded radioactive testosterone, androst-4-ene-3,17-dione and 11β-hydroxyandrost-4-ene-3,17-dione which were characterized by reverse isotope dilution techniques. These findings indicate the presence of C(17)—C(20) desmolase, steroid 11β-hydroxylase, 3β-hydroxysteroid dehydrogenase-isomerase and 17β-hydroxysteroid dehydrogenase enzymes in this tissue. Therefore, despite the deficient production of C19 3β-hydroxy-unsaturated steroids by the anencephalic foetus, as indicated by cord blood levels, a potential for synthesis of C19 3-oxo-4-unsaturated steroids has been demonstrated in vitro.
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