Rats were given a continuous intravenous infusion of aldosterone for up to 16 days. The rate of urinary Na+ excretion was initially depressed, but 'escape' occurred in about 4 days. Diurnal variation of Na+ excretion rate persisted even when the Na+ intake rate was controlled by infusion and when there was a continuous high level of exogenous aldosterone. After stopping aldosterone infusion, a transient rise in the rate of Na+ excretion was observed. Colonic transepithelial potential difference remained elevated as long as the infusion was continued and the short-circuit current, which is largely accounted for by active Na+ absorption, was increased. Stool Na+ content was reduced. The Na+ transport system of colonic epithelium, unlike that of kidney, does not appear to escape from the effect of aldosterone.
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