In recent years, research into the relationship between the pineal gland and reproductive function has yielded uncertain and often contradictory results (Chu, Wurtman & Axelrod, 1964; Thieblot, Berthelay & Blaise, 1966; Prop & Ebels, 1968; Wurtman, Axelrod & Kelly, 1968; Vaughan & Benson, 1970). The present investigation was designed to test the hypothesis that melatonin (an indole secreted by the pineal gland) inhibits ovarian activity in the adult female rat.
One hundred and eighty-three adult, virgin females (200–240 g initial body weight) of a CD strain of Sprague—Dawley rats were used. Animals were lightly anaesthetized with ether and the left ovary removed by a dorso-lumbar approach. In the first experiment, animals received 0·1, 0·5 or 2·5 mg melatonin (Mann Research Laboratories, New York, N.Y.) suspended in sesame oil (0·2 ml) s.c. for 9 days starting on the 11th postoperative day. One group received daily injections of 0·5 mg melatonin throughout
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Online ISSN: 1479-6805
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