Male guinea-pigs born to females injected with cyproterone acetate (CA) from day 28 to 58 of gestation developed non-tubular hypospadiac penes and stunted seminal vesicles and prostate glands. When adult animals were stimulated with exogenous or endogenous androgens, secretory failure and only minimal growth was observed in the accessory organs. The concentrations of endogenous testosterone in systemic plasma from intact CA males were not different from those in control males, but the uptake and distribution of [1,2-3H]testosterone in castrated CA males did not conform to control values. Deficiences in mounting, intromission and ejaculatory patterns were observed in CA males compared with controls. Lordosis, the primary behavioural response used as a criterion of 'feminization', was never observed in CA males even when large concentrations of oestrogens were administered. The results suggest that target organ insensitivity to testosterone in adulthood can be the result of deficient androgenic stimulation during embryological differentiation.
Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
| Sept 2018 onwards | Past Year | Past 30 Days | |
|---|---|---|---|
| Full Text Views | 1 | 1 | 0 |
| PDF Downloads | 3 | 3 | 0 |
Online ISSN: 1479-6805
Print ISSN: 0022-0795
Strengthening biomedical communities
to advance science and health
CONTACT US
Bioscientifica Ltd | Starling House | 1600 Bristol Parkway North | Bristol BS34 8YU | UK
Bioscientifica Ltd | Registered in England no 3190519
