Progesterone alters the mitotic and morphological responses of the mouse uterus to oestradiol-17β (Martin & Finn, 1968; Martin, Finn & Carter, 1970). The following experiment was done to see if the same effects occurred in the rat and whether or not the adrenal glands were necessary.
Forty female Sprague—Dawley rats (200–300 g) were spayed under sodium pentobarbitone anaesthesia. Twenty were also adrenalectomized and given 1% NaCl solution to drink. One week later all the animals were primed with three daily s.c. injections of 1 μg oestradiol-17β in arachis oil. After 2 days without treatment the animals were divided into groups and given the hormones shown in Table 1. 21 h after the last injection, each animal was given 0·75 mg demecolcine (Colcemid, Ciba) s.c. in water and killed 4 h later. At autopsy the success of adrenalectomy was checked visually. One horn of each uterus was fixed overnight in formol
Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
| Sept 2018 onwards | Past Year | Past 30 Days | |
|---|---|---|---|
| Full Text Views | 6 | 4 | 0 |
| PDF Downloads | 4 | 2 | 0 |
Online ISSN: 1479-6805
Print ISSN: 0022-0795
Strengthening biomedical communities
to advance science and health
CONTACT US
Bioscientifica Ltd | Starling House | 1600 Bristol Parkway North | Bristol BS34 8YU | UK
Bioscientifica Ltd | Registered in England no 3190519
