It is well established that administration of hypertonic saline brings about characteristic histological changes in the hypothalamic neurosecretory system (HNS), which are regarded as morphological manifestations of augmented secretion of the anti-diuretic hormone (ADH) (see Gabe, 1966). Reserpine is reported to stimulate (Chaudhury, Chaudhury & Lu, 1962; Guzek & Leśnik, 1968), inhibit (Moses, 1964; Bridges & Thorn, 1970), or to have no effect (Boris & Stevenson, 1967) on ADH secretion. The amount of neurosecretory material (NSM) after reserpine treatment has been found to be unchanged (Eränkö, Hopsa, Kivalo & Telkkä, 1957) or diminished (e.g. Gabe, Tuchmann-Duplessis & Mercier-Parot, 1961). The present study reports the effect of reserpine on the histology of the HNS of the musk shrew after treatment with hypertonic saline.
Animals were divided into six groups with 12 adults of either sex in each, and treated as follows: Group I: 3% NaCl solution (2 ml/day, i.p.) for 3–5
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