The 'facilitatory' activity of the retroprogesterone derivative 6-chloro-9β,10α-pregna-1,4,6-triene-3,20-dione (Ro 4-8347) on ovulation induced by pregnant mare serum gonadotrophin in immature Sprague—Dawley rats was studied. This retrosteroid is significantly more active in this test than progesterone, dydrogesterone (9β,10α-pregna-4,6-diene-3,20-dione) or chlormadinone (6-chloro-17α-acetoxy-pregna-4,6-diene-3,20-dione).
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