THE 'FACILITATORY'EFFECT ON OVULATION OF THE RETROSTEROID 1,6-DEHYDRO-6-CHLORO-RETROPROGESTERONE (Ro 4–8347)

in Journal of Endocrinology
Authors:
PUSHPA SETH KALRA
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L. MARTINI
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SUMMARY

The 'facilitatory' activity of the retroprogesterone derivative 6-chloro-9β,10α-pregna-1,4,6-triene-3,20-dione (Ro 4-8347) on ovulation induced by pregnant mare serum gonadotrophin in immature Sprague—Dawley rats was studied. This retrosteroid is significantly more active in this test than progesterone, dydrogesterone (9β,10α-pregna-4,6-diene-3,20-dione) or chlormadinone (6-chloro-17α-acetoxy-pregna-4,6-diene-3,20-dione).

 

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