Corticotrophin (ACTH) has been shown to increase adrenocortical DNA content (Bransome, 1968) and to stimulate adrenal DNA polymerase and thymidine kinase activity (Masui & Garren, 1970). Bransome (1968) has shown that dexamethasone also produces a significant decrease in adrenocortical DNA. It is therefore surprising that a recent report by Ueberberg, Stöcker & Städtler (1970) concluded that cell proliferation is not influenced by dexamethasone treatment. The present results indicate that in prepubertal rats dexamethasone has a profound inhibitory effect or adrenocortical cell proliferation by acting on a particular point in the cell cycle.
Male Wistar rats aged 14 days were given a single i.p. injection of 3 μg dexamethasone phosphate (Merck, Sharp and Dohme)/g body weight. Controls received normal saline. Animals were killed serially thereafter. Tritiated thymidine ([3H]Tdr) was administered 1 h before death, and autoradiographs of the adrenal glands prepared as previously described (Wright, 1971). The adrenal cortex was
Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
Sept 2018 onwards | Past Year | Past 30 Days | |
---|---|---|---|
Full Text Views | 0 | 0 | 0 |
PDF Downloads | 2 | 0 | 0 |