In late pregnancy the coefficient of variation of urinary 5β-pregnane-3α, 20α-diol from day to day is 24% in the same subject (Klopper, 1964). This variability is one of the factors which detracts from the value of pregnanediol assay. In 1959 Klopper & Macnaughton identified pregnanediol in faeces and suggested that a variable alimentary loss of pregnanediol might contribute to the variation in urinary pregnanediol. Davis, Plotz, Le Roy, Gould & Werbin (1956) measured the radioactivity recovered in the faeces after injection of [4-14C]progesterone but very little is known about the amount excreted in the faeces.
This study compares the urinary and faecal pregnanediol excretion during a 6-day period. All 12 subjects were between 30 and 34 weeks pregnant and had normal pregnancies. Complete urine and faecal collections were made for 6 days in a metabolic unit. Urinary pregnanediol was measured by the method of Klopper, Michie & Brown
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