Three neurophysins have been isolated and biochemically characterized from the ox (Rauch, Hollenberg & Hope, 1969), pig (Uttenthal & Hope, 1970) and sheep (Watkins, 1972) while the presence of a neurophysin has been demonstrated in cod pituitary glands (Pickering, 1968).
By means of immunological and biosynthesis techniques, Norstrom, Sjöstrand, Livett, Uttenthal & Hope, (1971) have tentatively identified one neurophysin in the rat posterior pituitary gland. In a recent extension of this work, Burford, Jones & Pickering (1971) using polyacrylamide electrophoresis have been able to resolve the major rat posterior pituitary gland protein into two major components one of which was tentatively described as an oxytocin-neurophysin and the other as a vasopressin—neurophysin.
In this present investigation, the neurophysins of the rat were fractionated using procedures previously established for the purification of the ox, pig and sheep neurophysins. The protein-hormone complex was prepared in a yield of 26·9 mg from an
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