THE EFFECT OF PROSTAGLANDIN F AND PROSTAGLANDIN E2 UPON LUTEAL FUNCTION AND OVULATION IN THE GUINEA-PIG

in Journal of Endocrinology
Authors:
F. R. BLATCHLEY
Search for other papers by F. R. BLATCHLEY in
Current site
Google Scholar
PubMed
Close
and
B. T. DONOVAN
Search for other papers by B. T. DONOVAN in
Current site
Google Scholar
PubMed
Close
Restricted access
Rent on DeepDyve

Sign up for journal news

SUMMARY

The effect of treatment with prostaglandin F (PGF on luteal function was examined in hysterectomized guinea-pigs. Regression of corpora lutea was found to occur when 0·25 mg (or more) was injected daily for 3 days and ovulation usually ensued within 5 days after treatment. The administration of 1 mg PGF daily for 7 days caused marked luteolysis but ovulation did not occur. Ovulation was blocked in three of four intact female guinea-pigs given 1 mg PGF/day for 7 days from day 15, but took place normally in five females injected with 0·25 mg/day. Treatment of hysterectomized guinea-pigs with 0·62 mg adrenaline hydrochloride/day, 1·97 mg atropine sulphate/day or 0·52 mg histamine dihydrochloride/day did not cause luteal regression, while the injection of 0·25 mg or 1 mg prostaglandin E2 daily for 3 days was likewise ineffective.

 

  • Collapse
  • Expand